It is known that the increase in the wall thickness and decrease in the smooth muscle cells along with increased collagen network area and decreased elastin function may be responsible for the stiffening of the basilar artery in aging (Hajdu et al. 1990; Fonck et al. 2009) and contribute to the development of atherosclerosis and vertebrobasilar insufficiency. The gene discussed is ELN; the disease is atherosclerosis.