Another mutation in LRP6 (R611C) has been identified in an Iranian family characterized with early CAD, features of the metabolic syndrome (hyperlipidemia, hypertension and diabetes), and osteoporosis [16], which significantly promoted PDGF-dependent vascular smooth muscle cells (VSMCs) proliferation compared to wild-type LRP6[17]. The gene discussed is LRP6; the disease is osteoporosis.