Although we failed to find any conclusive BRCA1 large genomic rearrangement and did not find any BRCA2 large genomic rearrangement in familial breast cancer patients and at risk individuals in the current study, a large study sample especially including Eurasians and other ethnic groups may reveal novel or reported genomic rearrangements among Sri Lankans. This evidence concerns the gene BRCA1 and breast carcinoma.