ENPP1 and pseudoxanthoma elasticum (inherited or acquired): The zebrafish dgf phenotype shows many of the features that have been described in the clinic as a consequence of ENPP1 mutation in the human syndromes GACI and PXE (Rutsch et al., 2003; Li et al., 2012; Nitschke et al., 2012), and that are observed in mouse upon mutation of Enpp1 (Johnson et al., 2003; Murshed et al., 2005; Mackenzie et al., 2012b; Li et al., 2013) – most notably, ectopic calcifications in the skin and cartilaginous elements of embryos, as well as in the eye and bulbus arteriosus of juvenile to adult fish.