We previously demonstrated that HCMV protein UL138 degrades the cell-surface ABC transporter Multidrug Resistance-associated Protein-1 (ABCC1) in both productive and latent infections and showed that the ABCC1-specific cytotoxic substrate Vincristine could be used therapeutically to eliminate cells latently infected with HCMV (Weekes et al., 2013). Here, ABCG2 is linked to disease arising from reactivation of latent virus.