Based on the proposed anti-tumoral role of the CD68-positive macrophage population in patients with primary CRC [57] and considering that liver provides the natural environment for proper functionality of the resident CD68-positive Kupffer cells, we extended our study by creating the CD68-attributed immunological imprint at CRCLM site and assessing the feasibility for disease-triggered cross-communication between B lymphocytes and macrophage lineage. The gene discussed is CD68; the disease is colorectal carcinoma.