Excess fat accumulation ultimately leads to development of hepatic steatosis and worsening hepatic insulin resistance via a network of transcription factors [7], which regulate hepatic lipogenesis and fatty acid oxidation, including sterol regulatory element-binding protein-1c (SREBP-1c), liver X receptor, and peroxisome proliferator receptors (PPARs). The gene discussed is SREBF1; the disease is Hepatic steatosis.