In attempt to find more potential axotrophin interaction partners or substrates, we used the LexA-axotrophin RING-variant domain fusion protein (pEG-axoCT) to screen an AD-related cDNA library and we identified the catalytical subunit of protein phosphatase 2B (PP2Ba, calcineurin) and kinesin light chain (KLC1) as positive clones in the yeast two-hybrid assay (Fig. 2). The gene discussed is KLC1; the disease is Alzheimer disease.