A significant up-regulation of Notch-3 expression was observed in nuclear (4.17±0.39; 4.74±0.18, p = 0.0001, p = 0.0001) and cytoplasm (3.67±0.36; 4.48±0.18, p = 0.0001, p = 0.0001) of precancer and cervical cancer of different stages as compared to normal cervix tissue (0.95±0.20, 0.70±0.20; p<0.001; p<0.001) respectively (Table-1, Figure-1H-K). This evidence concerns the gene NOTCH3 and cervical cancer.