NOTCH1 and cancer: A significant down-regulation of Notch-1 expression was observed in both nuclear (3.43±0.29; 2.04±0.19, p = 0.0001, p = 0.0001) and cytoplasm (3.07±0.29; 2.29±0.17, p = 0.0001, p = 0.0001) of precancer and cancer as compared to normal cervix tissue (5.40±0.19, 4.97±0.15; p<0.001; p<0.001) (Figure-1B-F).