Also, HPV-16 positive cervical carcinomas patients were observed to be associated with decreased cytoplasmic and nuclear Notch-1(3.7%, 3.7%, p = 0.0001, p = 0.0001) and with increased 93.9% of cytoplasmic Notch-3 and 95.1% of nuclear Notch-3. This evidence concerns the gene NOTCH3 and cervical carcinoma.