NOTCH3 and metastatic malignant neoplasm in the lymph nodes: However, Notch-3 was observed to be associated with lymph node metastasis (p = 0.03), increased smoking (p = 0.03), tobacco consumption (p = 0.02), vaginal involvement of tumor (p = 0.03), progressed tumor grade (p = 0.001) and FIGO stage (p = 0.03).