In the view of above, we measured both Notch-1 and Notch-3 expression levels in HPV associated various phases of tumor progression in the cervical epithelium, ranging from normal epithelium through low and high grades of squamous intraepithelial lesions (precancer) and invasive cervical cancer tissues to determine their role in this cancer. The gene discussed is NOTCH3; the disease is cervical carcinoma.