Promising results have also been obtained using various approaches including expression of Notch-1 ectodomain to inhibit tumor growth and angiogenesis [51], inhibiting γ-secretases and the ADAM metalloproteases that perform key activating cleavages of Notch [52], expressing dominant-negative fragments of Mastermind to modulate Notch signalling [51]. Here, NOTCH1 is linked to neoplasm.