CBL and pancreatic adenocarcinoma: For example, the demethylation of the vav1 gene promoter is detected in primary pancreatic adenocarcinomas [23]; methylation of CpG in 5′-regulatory sequences of the vav1 promoter is addressed in lung cancer cells [30]; and degradation of Vav1 through Cbl ubiquitination is proposed in breast cancer cells [27].