TTK and hepatocellular carcinoma: To investigate the role of TTK upregulation in hepatocarcinogenesis, TTK expression signal was analyzed using the gene expression profiling of multi-stage samples from liver lesions, including 24 regenerative (cirrhotic) nodules (CN), 3 low-grade (LGDN), 12 high-grade dysplastic nodules (HGDN) and 10 early hepatocellular carcinomas (Early HCC) [24].