Nevertheless, this finding that Mps1/AKT and B-Raf/ERK signaling form an auto-regulatory negative feedback loop in melanoma cells prompts possible associations between TTK-mediated sorafenib resistance and PI3K/Akt signaling pathway [43]; However, possible molecular mechanism involving in the role of TTK during hepatocarcinogenesis is worth further investigations. Here, BRAF is linked to melanoma.