Interestingly, many candidates including UBD, CENPF, CDC2, CCNB1, TTK, CCNA2, C18orf24, ECT2 and BUB1 were responsible for maintaining HCC cell proliferation, implying that these genes and protein products could be considered as potential therapeutic targets for HCC. This evidence concerns the gene CCNB1 and hepatocellular carcinoma.