The AKT pathway plays a pivotal role in transformation by inducing cell survival, growth, migration, and angiogenesis [13]–[17]._ENREF_13 Recently, we reported that increased activation of AKT is associated with multiple resistance of tumor cells to various cancer drugs, radiation, as well as cytotoxic T lymphocyte (CTL)-mediated cell death [18]–[21]. This evidence concerns the gene AKT1 and cancer.