Moreover, several isoforms of TRPC channels, dependent on the cell type, have been implicated in the CaSR activation-induced Ca2+ entry, such as TRPC3 in salivary ductal cells [10], TRPC1 in MCF-7 breast cancer cells [2] and keratinocytes [12], and TRPC6 in aortic smooth muscle cells [11] and cardiac myocytes [4]. This evidence concerns the gene TRPC1 and breast cancer.