Actually, in the present study, knockdown of Prx-I reduced protein expressions of phospho-NF-κB p50 and p65, and thus it suppressed growth, promoted apoptosis and regulated the cell cycle of bladder cancer cells by inhibiting the NF-κB pathway, which conformed to the IPA network (Figure 2C). The gene discussed is NFKB1; the disease is urinary bladder carcinoma.