TLR7 and TLR8 have already been shown to play a central role for the recognition of self RNA in the immunopathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), psoriasis, rheumatoid arthritis, Sjögren's syndrome and others (Demaria et al., 2010; Zheng et al., 2010; Theofilopoulos et al., 2011). The gene discussed is TLR7; the disease is systemic lupus erythematosus.