Phagocytosis of Bb by macrophages results in significant production of the anti-inflammatory cytokine IL-10, to mediate resolution of the already initiated cytokine response, a phenomenon which may play a critical role in Lyme disease severity and arthritis development (Lazarus et al., 2008; Gautam et al., 2012; Chung et al., 2013). This evidence concerns the gene IL10 and Arthritis.