This result fits well with a large body of evidence which demonstrates that β-catenin and E-cadherin are often down-regulated in cancer (17, 18, 51–54), reflecting the invasive properties of cancer cells and follows logically from a malignant cancer cell’s need to detach from neighboring cells through decoupling of adherens junctions and activation of Wnt/β-catenin signaling in order to invade neighboring tissue (55). This evidence concerns the gene CDH1 and cancer.