We specifically sought to test the hypotheses that (i) increased nuclear β-catenin staining is associated with poor outcome, indicating active Wnt/β-catenin signaling, that (ii) loss of β-catenin and E-cadherin membrane staining is associated with poor outcome due to decoupling of adherence junctions in epithelial–mesenchymal transition (EMT), and whether (iii) differential expression of the downstream Wnt signaling target, SOX9, identifies prognostic subgroups of CRC patients. This evidence concerns the gene SOX9 and colorectal carcinoma.