AGO2 and cancer: Preliminary analysis of data from The Cancer Genome Atlas consortium of multiple types of cancer through cBioPortal (80, 81) has shown a significant incidence of alterations in miRNA machinery genes (Table 1), especially the AGO2 gene, which has a high incidence of gene alterations across cancer types, including breast invasive carcinoma (23.30%), colon and rectum adenocarcinoma (12.3%), bladder urothelial carcinoma (20.8%), and prostate adenocarcinoma (20.7%).