Because HDAC3 knock-down suppresses cell viability and contributes to DNA damage and disruption of DNA repair (18, 36, 66, 72), we hypothesized that HDACi compounds with HDAC3 bias will be synergistic with DNA damaging agents in ovarian cancer cells and found that FK228, a class I HDACi that potently inhibits HDAC3, enhances the effects of cisplatin in vitro and in vivo (73). Here, HDAC3 is linked to ovarian carcinoma.