Results from IEL T cell analyses in prolapse-free CD4cre:PP4f/f mice (Figure 5 and S2B), from helper T cell polarization (Figure 6C), and from the induction of experiment colitis (Figure 6E) also helps rule out the possibility that PP4 deficiency induces novel pro-inflammatory, colitogenic effector CD4 T cells. This evidence concerns the gene CD4 and colitis.