After Treg depletion followed by Her-2 DNA and mouse Tg injections, tumor rejection was similar in Her-2 transgenic mice expressing either Ab or Ab/DR3, but thyroiditis was augmented only in (Ab/DR3)F1 mice, showing that Her-2 immunity, unlike autoimmunity, was independent of DR3 expression. The gene discussed is TNFRSF25; the disease is thyroiditis.