Infection of the hepatocyte sub-line Huh7.5.1 with JFH1 (2a) induced an acute ER stress peaking at 2–5 days post-infection (dpi), concomitant with phosphorylation of IRE1, eIF2α, and JNK, XBP1 splicing, ATF6 cleavage and upregulation of GADD34, ERdj4, P58IPK, ATF3, ATF4, and CHOP (Merquiol et al., 2011). This evidence concerns the gene ATF6 and infection.