CXCL10 and airway hyperresponsiveness: HRV-infected BECs secrete a wide range of cytokines and chemokines such as IL-1, IL-6, CCL5/RANTES (regulated on activation, normal T cell expressed and secreted), CXCL8/IL-8, GM-CSF, and CXCL10/interferon-inducible protein 10 (IP-10; Jackson and Johnston, 2010; Proud, 2011), which induce neutrophilic, lymphocytic, and eosinophilic inflammation together with airway hyperresponsiveness and airway remodeling (Wark et al., 2002; Proud, 2011).