GJA1 and central nervous system cancer: Along with the role of Cx43 as a channel in glioma, studies show that Cx43 can act as a tumor suppressor gene, as well (Zhu et al., 1992; Goodenough et al., 1996; Omori and Yamasaki, 1998; Huang et al., 1999; Zhang et al., 2003a).