A number of experiments on Cx Knockout mice (Cx43, Cx30, Cx32, Cx47) showed massive demyelination in the EAE model inferring the role for connexin in demyelinating diseases such as MS (Menichella et al., 2003; Lutz et al., 2009; Magnotti et al., 2011). This evidence concerns the gene GJC2 and demyelinating disease.