TLR4 and systemic sclerosis: The inhibition of TLR4 has been reported to antagonize AngII-induced cardiac fibrosis (Wang et al., 2014), the activity of TLR4 in hepatic stellate cells enhances liver fibrosis (Seki et al., 2007), and the activity of TLR4 in skin fibroblasts enhances SSc (Bhattacharyya et al., 2013).