Interestingly, despite no effect of the vitamin trials on lowering the incidence of preeclampsia, antioxidant supplementation led to a significant decrease in the plasma concentration of sFlt-1 and an increase in the plasma concentration of PlGF (Poston et al., 2011), matching our in vitro findings and confirming the beneficial effect of antioxidants on VEGF signaling. Here, VEGFA is linked to preeclampsia.