Immunohistochemical analysis also showed that LRP1-positive vessels were reduced in patients with AD (Shibata et al., 2000) and cerebrovascular β-amyloidosis Dutch-type compared to controls (Deane et al., 2004), although there are also conflicting reports (Donahue et al., 2006; Wilhelmus et al., 2007). Here, LRP1 is linked to Alzheimer disease.