LRP1 and Alzheimer disease: Low-density lipoprotein receptor-related protein 1 ligands, specifically apoE, α2M, tPA, uPA, plasminogen activator inhibitor-1, lipoprotein lipase, and lactoferrin co-deposit with Aβ in senile plaques in AD brains (Namba et al., 1991; Rebeck et al., 1995).