5-HT1A post-synaptic receptors have been found to be necessary for antidepressant effects; hence, 5-HT1A autoreceptor selective antagonism coupled with post-synaptic 5-HT1A receptor agonism is thought to produce antidepressant effects (see Bipolar Versus Unipolar Depression: Data from Animal Models). The gene discussed is HTR1A; the disease is major depressive disorder.