Reduced non-social but increased social anxiety have been reported in Fmr1 KO mice (Bakker et al., 1994; Peier et al., 2000; Mineur et al., 2002; Spencer et al., 2005; Mineur et al., 2006) but the anxiety phenotype of Fmr1 KO mice has not been consistent in all studies (Van Dam et al., 2000; Mineur et al., 2002; Nielsen et al., 2002; Zhao et al., 2005; Bernardet and Crusio, 2006). The gene discussed is FMR1; the disease is Anxiety.