From those genes, only Kif3a and Kif1b or related molecules have been studied in the context of kinesin dysfunction or impaired anterograde transport of cargos, like neurofilament, in ALS (Dupuis et al., 2000; Conforti et al., 2003; Pantelidou et al., 2007). This evidence concerns the gene KIF1B and amyotrophic lateral sclerosis.