ALS2 and amyotrophic lateral sclerosis: Furthermore, despite ALS2 deficiency accounts for ALS2 familial form (Hadano et al., 2001; Yang et al., 2001), the upregulation of Als2 seen in the 60 days old presymptomatic ALS sciatic nerve could reflect a transient Schwann cell neuroprotective paracrine response (Hadano et al., 2010).