The ability of CXCL12 to guide GBM cell migration has been widely supported by in vitro experiments (Rubin et al., 2003; Bajetto et al., 2006) and, although the molecular mechanisms involved are not definitively identified, the effect of CXCL12 results from a functional cooperation with EGFR and PDGFR, overexpressed in GBM cells (Woerner et al., 2005; Sciaccaluga et al., 2013). The gene discussed is PDGFRB; the disease is glioblastoma.