The interaction of GBM cells with the microenvironment that protects cancer cells from the chemo- and radio-therapy stress, becomes even more relevant in the context of CXCL12/CXCR4 up-regulation observed after treatment with anticancer drugs, and particularly after anti-VEGF antibodies (Shaked et al., 2008; Kioi et al., 2010; Keunen et al., 2011). This evidence concerns the gene CXCL12 and glioblastoma.