The significance of the expression and function of the CXCL12/CXCR4 axis in brain tumors has been intensely investigated in adult and children GBM, astrocytoma, medulloblastoma, oligodendroglioma, and oligodendroastrocytoma (Domanska et al., 2011). This evidence concerns the gene CXCR4 and astrocytoma (excluding glioblastoma).