A role for CXCL12 modulation of CXCR4 and CXCR7 was identified for most of the brain tumors including gliomas, meningiomas and even pituitary adenomas that frequently overexpress these receptors (Bajetto et al., 2007; Barbieri et al., 2007; Duda et al., 2011). This evidence concerns the gene CXCL12 and central nervous system cancer.