As previously detailed, CXCL12 modulates tumor cell proliferation, angiogenesis and metastasis, acting as an autocrine/paracrine growth factor (Barbero et al., 2003; Barbieri et al., 2008; Pattarozzi et al., 2008), representing a promising target for the treatment of neoplasia. The gene discussed is CXCL12; the disease is neoplasm.