The five-transmembrane domain glycoprotein CD133 (prominin-1), initially reported as one of the most reliable markers to identify GBM CSCs (Beier et al., 2007), although conflicting reports were subsequently published and not labeling all CSC subpopulations, is still considered a key component of CSCs (Grosse-Gehling et al., 2013) acting as a regulator of cell survival inducing PI3K-Akt activation, via a direct interaction with p85 (Wei et al., 2013). This evidence concerns the gene PROM1 and glioblastoma.