GBM cells, organized around neuron and blood vessels in subpial regions and in white matter express high levels of CXCR4: VEGF-dependent CXCL12 up-regulation in neuronal and endothelial cells induces the migration of CXCR4-positive GBM cells, representing the molecular mechanisms of Scherer’s structure formation (Ehtesham et al., 2006; Zagzag et al., 2008; Munson et al., 2013). This evidence concerns the gene CXCL12 and glioblastoma.