Considering that NALCN channel is expressed in pancreatic islets, both in α- and β-cells, and is possibly involved in the regulation of insulin secretion (Kutlu et al., 2009 and http://t1dbase.org; Swayne et al., 2010), targeting NALCN might be relevant to treat type 2 diabetes. The gene discussed is NALCN; the disease is type 2 diabetes mellitus.