As NKCC1 inhibitor bumetanide is an FDA-approved loop diuretic extensively used in the past with very mild side effects (Kahle and Staley, 2008), clinicians were readily allowed to perform clinical trials on the use of bumetanide to treat infant and adult epilepsy, and more recently autism in young patients with encouraging results (Kahle et al., 2009; Lemonnier and Ben-Ari, 2010; Lemonnier et al., 2012; Eftekhari et al., 2013; Hadjikhani et al., 2013). Here, SLC12A2 is linked to epilepsy.