SOD1 and amyotrophic lateral sclerosis: Actually, only some ALS cases (less than 10%) have been linked to mutations in a number of genes, including in the enzyme Cu, Zn superoxide dismutase 1 (SOD1), TAR DNA binding protein (TDP-43), fused in sarcoma (FUS), optineurin (OPTN), valosin-containing protein (VCP), ubiquilin 2 (UBQLN2), profilin 1 (PFN1), and chromosome 9 open reading frame 72 (C9ORF72) repeat expansions (Tovar et al., 2009a; DeJesus-Hernandez et al., 2011; Ince et al., 2011; Renton et al., 2011, 2014; Bertolin et al., 2013).