Evidence for the role of miRNAs in MN diseases is substantiated by the relevance that the proteins TDP-43 and FUS/TLS, responsible for the processing of miRNAs, RNA maturation and splicing (Kiernan et al., 2011), have recently acquired in ALS (Lagier-Tourenne and Cleveland, 2009; Haramati et al., 2010). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.