Reactive astrogliosis in ALS was first revealed in 1990s by increased GFAP staining in the subcortical white matter (Kushner et al., 1991), and later on similarly observed in the ventral and dorsal horns of the SC, as well as in the transition between gray matter and anterior and lateral funiculi, where the dystrophy of neuritis exists (Schiffer et al., 1996). The gene discussed is GFAP; the disease is amyotrophic lateral sclerosis.