Although only a few studies have examined whether oligodendrocytes or myelin sheaths have a role in ALS, the myelin abnormalities consisting in loss of compact myelin and lamellae detachment in the SC of pre-symptomatic SOD1 transgenic rats and aggravated at symptomatic stages (Lasiene and Yamanaka, 2011) suggest that it may be an interesting target for further study. Here, SOD1 is linked to amyotrophic lateral sclerosis.