SOD1 and amyotrophic lateral sclerosis: SOD1 aggregates are observed in both genetic and non-genetic ALS cases, but their contribution to MN toxicity remains to be established, although deregulation of Golgi, endoplasmic reticulum (ER), and mitochondria, together with axonal transport defects have been indicated (for review, see Boillée et al., 2006a; Rothstein, 2009).