TARDBP and amyotrophic lateral sclerosis: Actually, cytoplasmic aggregation of nuclear TDP-43 and FUS in the degenerating neurons and glia of ALS patients, and release of the accumulated cytoplasmic mutant SOD1 (mSOD1) to the extracellular space that can be taken up by other cells, are common features (Li et al., 2013; Ogawa and Furukawa, 2014).