SOD1 and amyotrophic lateral sclerosis: Transgenic mice containing other mSOD1 genes (G85R, G37R, D90A, or G93A missense mutations or truncated SOD1) and the related mutant (G86R) mouse have also shown progressive neurodegeneration of the motor system and resemblance to ALS (for review, see Van Den Bosch, 2011).