GSK3B and Cognitive impairment: In this regard, we have demonstrated that neuronal GSK-3β overexpression causes a drastic decrease in postsynaptic density number and volume in hippocampal granule neurons (Llorens-Martin et al., 2013), a phenomenon that may be related to cognitive impairment and altered LTP generation previously observed in these mice (Hernandez et al., 2002; Hooper et al., 2007).