Other studies had postulated that vascular dysfunction contributes to the etiology of POAG (Henry et al., 1999; Feke and Pasquale, 2008; Su et al., 2008) and systemic vascular dysfunction had been previously reported in sGCα−/−1 mice (Nimmegeers et al., 2007; Atochin et al., 2010; Buys et al., 2012). This evidence concerns the gene SGCA and open-angle glaucoma.