This was a particularly interesting finding in light of the identification of sGCα−/−1 mice with systemic and retinal vascular dysfunction, as a model of POAG with moderately elevated IOP: as described above, POAG patients with early paracentral visual field loss tend to have more frequent systemic vascular risk factors (Park et al., 2011, 2012), and low OPP is a risk factor for POAG (Leske, 2009; Cherecheanu et al., 2013). Here, SGCA is linked to open-angle glaucoma.