sGC itself can be converted to an NO-insensitive state as a consequence of increased oxidative stress: it is conceivable that the mechanism by which increased oxidative stress results in POAG (Majsterek et al., 2011a) may involve direct oxidation and inactivation of sGC (Stasch et al., 2006). The gene discussed is SGCB; the disease is open-angle glaucoma.