Mice lacking the α1 subunit of the NO receptor soluble guanylate cyclase (sGCα−/−1 mice) were recently reported to represent a novel and translatable animal model of POAG, characterized by thinning of the retinal nerve fiber layer (RNFL) and loss of optic nerve axons (Buys et al., 2013). The gene discussed is SGCA; the disease is open-angle glaucoma.