And thirdly, in a recent candidate gene association study in POAG patients from the GLAUGEN cohort (Wiggs et al., 2011), a variant (rs11722059) was identified in the GUCY1A3/GUCY1B3 locus (containing the genes encoding the α1 and β1 subunits of sGC, arranged in tandem) (Wiggs et al., 2011). The gene discussed is SGCB; the disease is open-angle glaucoma.