Our current study provided experimental evidence demonstrating that PNS and its major bioactive components Rg1, Rb1 or R1 exert a significant therapeutic effect on a complex disease condition featuring concomitant presentation of lewis lung carcinoma and myocardial ischemia in mouse, in which the effective therapies are confounded by paradoxical angiogenic processes in growing tumor and ischemic heart, respectively. This evidence concerns the gene RB1 and myocardial ischemia.