It has been demonstrated that FoxO3a in re-expressed in neuroblastoma cells treated with the DNA methylation inhibitor 5-aza-2-deoxycytidine.26 Moreover, the same inhibitor was related to dephosphorylation and nucleus translocation in acute leukemia.27 This suggests the DNA methylation regulation of FoxO3a gene in cancer. This evidence concerns the gene FOXO3 and cancer.