FOXO3 and acute leukemia: It has been demonstrated that FoxO3a in re-expressed in neuroblastoma cells treated with the DNA methylation inhibitor 5-aza-2-deoxycytidine.26 Moreover, the same inhibitor was related to dephosphorylation and nucleus translocation in acute leukemia.27 This suggests the DNA methylation regulation of FoxO3a gene in cancer.