RYR2 and Alzheimer disease: Interestingly, RyR-mediated ER Ca2+ homeostasis deregulation in AD was supported by the finding showing that exacerbated IP3R-evoked Ca2+ signals in the PS1M146V- and the 3xTg-AD-derived neurons occur through increased RyR-mediated CICR (Ca2+-induced Ca2+ release) (Figure 2)[72].