Importantly, we and other laboratories showed that dantrolene diminishes Aβ load, and reduces Aβ-related histological lesions in three different AD mice models (Tg2576, 3xTg-AD and PS1M146V/APPswe), demonstrating that subchronic blockade of RyR activity may be beneficial in the context of AD[92,134,135]. This evidence concerns the gene RYR2 and Alzheimer disease.