MCAM and neoplasm: Thus, we are convinced that the lack of MCAM/MUC18 expression, as documented in the six clinically advanced patients, is a real biological status. These data are supported by the clinical course and outcome of these patients, as statistically reported in Table 2; moreover, when possible, molecular MCAM/MUC18 expression was correlated at t0 to the immunohistochemical negative staining on the primary tumours.