In our subset of melanoma tissues immunohistochemically tested, MCAM/MUC18 staining showed a consistent cytoplasmatic expression in melanoma cells interestingly related to an increased tumour burden, as observed on nude mice where a significant correlation between MCAM/MUC18 and metastatic growth was revealed [20, 27, 29, 35, 62]. The gene discussed is MCAM; the disease is neoplasm.