CCND1 and acute myeloid leukemia: To determine whether c-Myc affects proliferation of AML cells, we first silenced c-Myc (Figure 4A and B) and found significant reduction of cyclin D1 mRNA level by 49.53±2.43% (p = 0.006), and marked elevation of p21 mRNA level by 105.36±42.94% (p = 0.015), to negative controls, respectively (Figure 4C).