Oxidative damage may lead to enhanced amyloid beta peptide (Aβ) production [21]–[24] and in a recent study, Cenini et al. showed that soluble and insoluble Aβ and oligomers increase as a function of age in DS frontal cortex, and that Aβ40 correlated with protein carbonyls (an oxidative stress marker), which suggests that oxidative damage may contribute to the onset and progression of AD pathogenesis in DS [25]. Here, APP is linked to Alzheimer disease.