PTEN and cancer: The allele analysis revealed that (−) allele of PTEN IVS4 (rs3830675) polymorphism was significantly associated with increased risk of cancer (OR = 1.30, 95% CI = 1.12–1.50, P = 0.001, Figure 4) and digestive tract cancer (OR = 1.42, 95% CI = 1.16–1.74, P = 0.001) compared with (+) allele.