However, subgroup analysis based on different cancer type indicated that PTEN IVS4 (+/−) genotype was significantly related with increased risk of digestive tract cancer (OR = 1.33, 95% CI = 1.05–1.68, P = 0.016); while no such association was detected in subgroups of breast cancer or prostate cancer. The gene discussed is PTEN; the disease is breast carcinoma.