It was worth noting that subgroup analysis of population-based (PB) and hospital-based (HB) demonstrated controversial outcomes (PB: OR = 1.31, 95% CI = 1.07–1.59, P = 0.007; HB: OR = 0.63, 95% CI = 0.41–0.96, P = 0.033), which suggested that the selection of the controls might influence the result of the relation between PTEN IVS4 (+/−) genotype and cancer risk. Here, PTEN is linked to cancer.