PTEN and cancer: The recessive effect model and dominant effect model also demonstrated significant association between PTEN IVS4 (rs3830675) polymorphism and increased cancer risk (−/− vs. (−/+ and +/+): OR = 1.56, 95% CI = 1.19–2.05, P = 0.001, Figure S2; (−/+ and −/−) vs. (+/+): OR = 1.26, 95% CI = 1.06–1.49, P = 0.008, Figure S3) especially for digestive tract cancer (−/− vs. (−/+ and +/+): OR = 1.70, 95% CI = 1.16–2.49, P = 0.007; (−/+ and −/−) vs. (+/+): OR = 1.45, 95% CI = 1.16–1.81, P = 0.001).