MBP and microcephaly: Its consequences can include progressive hydrocephalus, gray matter migration abnormalities, loss of parenchymal brain tissue, agenesis of the corpus callosum, and delayed or abnormal maturation of white matter, that is, reduced MBP (myelin basic protein) expression, diminished total axon volume, trisomies, and microcephaly (Bigler 1987; Gilmore et al. 1998, 2001, 2008; Griffiths et al. 2010; Kuban et al. 1999; Kyriakopoulou et al. 2014, Manfredi et al. 2010).