Several cardiac transcripts were shown to be directly regulated via βAR-mediated EGFR transactivation, including Sema3f, Thbs1 and Aplnr. Sema3f encodes semophorin 3F (Sema3F), a member of a large family of secreted and membrane-bound factors that influence cardiac innervation [25], inhibit angiogenesis [26], [27] and tumor invasion [28]. This evidence concerns the gene APLNR and neoplasm.