βAR-mediated transactivation of EGFR has been shown to relay cardiac survival in a mouse model of heart failure [3], but aside from ERK1/2 activation in a variety of cell types [4], [13], [14] and DNA synthesis in fibroblasts [15], the mechanisms by which protection are conferred via this process have not been well established. The gene discussed is EGFR; the disease is heart failure.