Table 5 lists enriched GO terms and their corresponding significant levels. Many studies from the fields of structural biology, translational biology, and immunology demonstrate that factor H recognizes and binds to self-surfaces via sialic acid and glycosaminoglycan (GAG) chains of proteoglycans, whereupon its complement-regulating properties were enhanced. The interaction between glycosaminoglycans (GAGs) and CFH plays an important role in the disease pathology of age-related macular degeneration [43]–[52]. The gene discussed is CFH; the disease is age-related macular degeneration.