Then to confirm whether the chaperone activity of Hsp90 is required for viral capsid protein ICP5 expression, Hsp90 inhibitor 17-AAG and BJ-B11 were used to treat HSV-1-infected cells, and the expression level of ICP5 and Hsp90 at different time points after infection was measured respectively (Fig. 5A). The gene discussed is HSP90AA1; the disease is infection.