Inside tissues, CLL cells also experience a chronic antigen contact that implies the engagement of the B cell receptor (BCR) signaling, leading to activation of downstream pro-survival signaling molecules such as nuclear factor-kB, Raf, mitogen-activated protein kinase MEK and extracellular signal regulated kinase (ERK) [4]. The gene discussed is MAP2K7; the disease is B-cell chronic lymphocytic leukemia.