However, if stimulated with ET-1 peptide, the blockade of ETAR by 0.1 μM and 1 μM BQ-123 abrogated the ET-1-induced apoptosis resistance, decreasing CLL viability to 24%±12% and 20%±11% respectively (p = 0.003 and p = 0.004, Figure 2B and Figure S2 in File S1). The gene discussed is EDN1; the disease is B-cell chronic lymphocytic leukemia.