As shown in Figure 5, higher levels of big ET-1 were detected in patients with advanced Binet stage (median, 3.5, 4.2 and 9.8 pg/mL in stage A, B and C respectively, p = 0.004), unmutated IGHV status (median, 3.4 and 5.0 pg/mL in mutated and unmutated IGHV CLL subsets, p = 0.003), intermediate/high FISH risk (median, 3.3 and 5.1 pg/mL in low and high FISH risk subsets, p = 0.002). The gene discussed is EDN1; the disease is B-cell chronic lymphocytic leukemia.