EDN1 and B-cell chronic lymphocytic leukemia: In particular, a progressive increase in big ET-1 levels characterized CLL with hierarchically ranked FISH abnormalities (3.2, 3.5, 4.3, 5.0 and 5.9 pg/mL in CLL with normal FISH, 13q deletion, trisomy 12, 11q and 17p deletions respectively) (Figure 5A).