MCL1 and small cell lung carcinoma: Indeed, efficient knock-down of MCL1 by lentiviral shRNAs greatly enhances the inhibitory activity of BM-1197 in 4 of 5 resistant SCLC cell lines (Fig 12A) and the ability of BM-1197 to induce PARP cleavage (apoptosis) in these 4 cell lines (Fig 12B).