Consistent with this finding, a recent publication by Roberts et al. [35], found that the presence of the CARD8-rs2043211 T allele in combination with the NLRP3-rs35829419 C allele conferred a protective effect against Crohn’s disease (CD) in Caucasian individuals (OR: 0.35, 95% CI: 0.15–0.82 and OR: 0.66, 95% CI: 0.48–0.90 for CARD8 1,1/NLRP3 1,2 and CARD8 1,2/NLRP3 1,1, respectively). This evidence concerns the gene NLRP3 and Crohn disease.