Interestingly, NLRP12 and NLRX1, two known NF-κB negative regulators, were markedly down-regulated, and NFKB1 as well as several NF-κB target genes encoding pro-inflammatory cytokines (IFNB1, IL12B, IL6 and TNF), chemokines (CXCL1, CXCL2, CCL5) and molecules involved in carcinogenesis (PTGS2 and BIRC3) were markedly up-regulated, in THP-1 cells infected with a highly virulent H. pylori strain isolated from a GC patient. The gene discussed is NLRP12; the disease is gastric cancer.