BIRC3 and cancer: Further, because baculoviral IAP repeat containing 3 (BIRC3), also known as cellular inhibitor of apoptosis protein 2 (cIAP2), is a member of the inhibitor of apoptosis protein (IAP) family, and is over-expressed in most cancer tissues [59], it can be postulated that stimulus with H. pylori GC026 elevates the already high basal levels of BIRC3 in THP-1 cells, a cell line derived from an acute monocytic leukemia patient.