In the context of gastrointestinal carcinogenesis, Zaki et al. [55] have demonstrated that NLRP12 plays an essential role in the suppression of pro-inflammatory cytokines and chemokines by controlling the activation of NF-κB and extracellular-signal-regulated kinase (ERK) pathways in response to microbial components, colon inflammation and colorectal tumorigenesis. This evidence concerns the gene NFKB1 and colitis.