CARD8, located at 19q13, encodes the caspase recruitment domain protein 8 (CARD8), also known as TUCAN, which has been reported to interact with NLRP3, suppress NF-κB activating signals and be overexpressed in human cancer tissues including ovarian, lung and breast cancer tissues [25]–[27]. This evidence concerns the gene NFKB1 and breast carcinoma.