Strikingly, individuals harbouring ten of the selected polymorphisms (CARD8-rs10405717, NLRP3-rs12079994, NLRP3-rs3806265, NLRP3-rs4612666, NLRP12-rs2866112, NLRP12-rs4419163, NLRX1-rs10790286, CASP1-rs2282659, CASP1-rs530537 and CASP1-rs61751523) and infected with H. pylori were observed to be at most risk of GC, the majority of these ORs being in the range 4.0–5.0 (Table 3). Here, NLRP3 is linked to gastric cancer.