RB1 and retinoblastoma: In recent years, genetic characterization of retinoblastomas beyond loss of RB1 has provided multiple potential targets for therapeutic intervention (reviewed in [3]), including the oncogenes KIF14[4], MYCN[2], E2F3[5], DEK[5], MDM4[6] and SYK[7], the tumor suppressor cadherin-11 [8], and the oncomiR cluster 17∼92 [9].